Pathological and functional amyloid formation orchestrated by the secretory pathway.
2003
Amyloidogenesis has historically been associated with pathology in a class of neurodegenerative diseases known as amyloid diseases. Recent studies have shown that proteolysis by furin during secretion initiates both variant gelsolin amyloidogenesis, associated with the disease familial amyloidosis of Finnish type, and Pmel17 fiber formation, which is necessary for the functional biogenesis of melanosomes. Proteolysis combined with organelle-dependent environment changes orchestrate amyloidogenesis associated with both pathological processes and a functional pathway.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
101
References
64
Citations
NaN
KQI