A case of primary peripheral T-cell type non-Hodgkin lymphoma originating in the iris: Clinico-pathological findings
2010
Background. The ocular adnexal region is the primary localization of
extranodal lymphoma in 5% to 15% of all Non-Hodgkin lymphoma. Intraocular
lymphoma of T-cell origin is extremely rare and such sites of infiltration
have been rarely observed in clinical examination. Case report. We presented
a 56-year-old man with iris infiltration by primary intraocular peripheral
T-cell lymphoma. The patient was in clinical stage I BE and the treatment was
initiated according to cyclophosphamide, hydroxydaunorubicin, oncovin,
prednisone (CHOP) regimen. When the second course of the therapy was
scheduled, the patient developed central nervous system lymphoma
infiltration. Although De Angelis regimen was used, 3 months after the
diagnosis was established, lethal outcome ensued due to disease progression.
Conclusion. According to our experience we can conclude that further
therapeutical approach to patients with primary intraocular Tcell lymphoma
requires modification of conventional treatment regimens. The lower median
survival in these patients suggests that the disease may be of more
aggressive course.
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