Body composition and adiponectin serum concentrations in adult patients with cystic fibrosis.

Context: Cystic fibrosis (CF) is a disease characterized by weight loss and chronic low-grade inflammation. Objective: The objective of the study was to assess changes in body composition and the serum concentrations of adiponectin, a marker of negative energy balance and insulin sensitivity, in adult patients with CF. Design: This was a cross-sectional study. Setting: The study was conducted at an outpatient clinic of the University Hospital of Basel, Switzerland. Participants: Twenty-four stable adult CF patients and 24 healthy controls, matched for body mass index, age, sex, and hormonal therapy in women participated in the study. Main Outcome Measures: Changes in body composition (assessed by dual x-ray absorptiometry) and serum adiponectin levels were measured. Results: Body mass index, percent fat mass (in percentage of body weight), and percent lean body mass were similar in patients and controls, whereas central fat accumulation was increased [trunk to extremity fat ratio 1.2 (0.99–1.51) vs. 0.99 ...