Principles and practice of immunotoxicology

Part 1 The basis of the immune system - cells of the immune system regulation of the immune system by pharmacological and biological mediators homeostatic mechanisms in the immune response. Part 2 Immunotoxicology (current concepts): toxic consequences of chemical interactions with the immune system adverse immunological effect of drugs and other chemicals and methods to detect them contact sensitivity the lung as a target organ intolerance and allergic reactions to food components and additives the effect of nutrition on the immune system psychoneuroimmunology interaction between the immune system, endocrine system and nervous system. Part 3 Specific examples relating to the immunotoxic/health effects of chemicals: mineral dusts - asbestos, silica and others occupational asthma and allergic reactions to inhaled chemicals PCB intoxication TCDD intoxication, toxic oil and others. Part 4 Methods of assessing immunotoxic events in experimental systems: hypersensitivity - adverse drug reaction histopathological approaches specific immuno function assays integrating in vitro systems with animal models in mechanistic studies of immunotoxic agents molecular immunotoxicology concluding remarks.