2‐Methyl‐2‐(trimethylsilyloxy)‐3‐pentanone

[72507-50-7] C9H20O2Si (MW 188.38) InChI = 1S/C9H20O2Si/c1-7-8(10)9(2,3)11-12(4,5)6/h7H2,1-6H3 InChIKey = BLYRAXGLJVABLF-UHFFFAOYSA-N (lithium enolate used in the synthesis of syn-β-hydroxy acids, aldehydes, and ketones) Physical Data: bp 71–75 °C/15 mmHg. Preparative Methods: prepared in four steps from propionaldehyde in 14–33% overall yield;2 in three steps from Acetone Cyanohydrin in 40% overall yield;3 and in two steps from 3-hydroxy-3-methyl-2-butanone in 55% overall yield.4 Handling, Storage, and Precautions: use in a fume hood.