ALL-234: TLE1 Gene Expression in Adult T-Cell Acute Lymphoblastic Leukemia

Background: Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes. The aim of this study was to evaluate the prognostic role of TLE1 gene expression in patients with T-cell acute lymphoblastic leukemia (T-ALL). Method: This study was conducted on 97 newly diagnosed T-ALL patients admitted to the Mansoura University Oncology Center (59 males and 38 females), with a median age of 33 years, in addition to 102 apparently healthy individuals who served as a control group. TLE1 gene expression was measured in both the patient and control groups by real-time PCR. The calculation of relative gene expression was done using the δδCt: method. Results: TEL1 gene expression was significantly downregulated in T-ALL cases (median 2.83) compared to controls (median 84.65; P Conclusion: TLE1 gene expression was significantly downregulated in T-ALL compared with controls. Low TLE1 expression is an independent predictor of T-ALL patient outcomes and could open avenues for further risk stratification and targeted therapy in T-ALL.