Lorcaserin hydrochloride sustained-release capsules and preparation method thereof

The invention belongs to the field of medicines and relates to a lorcaserin hydrochloride sustained-release capsule and a preparation method thereof. The sustained-release capsule comprises lorcaserin hydrochloride sustained-release pellets and a capsule shell, wherein each lorcaserin hydrochloride sustained-release pellet comprises a pill core and a sustained-release layer wrapping the pill core; the pill cores comprise 6wt% of lorcaserin hydrochloride or lorcaserin hydrochloride hemihydrates, 60-64wt% of sucrose powder, 20-24wt% of starch and 6-14wt% of microcrystalline cellulose; the sustained-release layers comprise 30-36wt% of polyacrylic resin S100, 30-36wt% of ethyecellulose, 4-8wt% of high-substituted hydroxyproxyl cellulose, 18-22wt% of dibutyl sebacate and 6-10wt% of talcum powder. The lorcaserin hydrochloride sustained-release capsule is stable in property and reliable in quality. A patient needs to take one common lorcaserin hydrochloride tablet twice every day, but only needs to take the hydrochloride sustained-release capsule prepared by the invention once every day, so that the compliance of the patient is improved.