Tetrahydroquinolines to use as modulators of mitotic motor protein Eg5 the.

Compounds of formula I ** ** Formula where mean: W CH or N, R1, R2, R3 independently of one another, H, A, aryl, heteroaryl, Hal, - (CY2) n-SA, - (CY2) n-SCF3, (CY2) n-SCN, - (CY2) n-CF3, - (CY2) n OCF3, cycloalkyl, -SCH3, -SCN, -CF3, -OCF3, -OA, - (CY2) n- OH, (CY2) n-CO2R, - (CY2) n-CN, - (CY2) n-Hal, (CH2) nR, - (CY2) n-NR2, (CY2) n-OR, (CY2) n- OCOA, -SCF3, (CY2) nCONR2, - (CY2) n-NHCOA, - (CY2) n-NHSO2A, SF5, Si (CH3) 3, CO- (CY2) n CH3, - (CY2) nN-pyrrolidone , (CH2) nNRCOOR, NRCOOR, NCO, CH2 (CH2) nCOOR, NHCOOR, CH2 (CH2) nOH, NR (CH2) nOH, CH2NH2, (CH2) nNR2, CH (OH) R2, CH2NHCOR, (CH2) narilo, CH2 (CH2) nheteroarilo, (CH2) NR1, NH (CH2) nCOOR, CH2 (CH2) nX (CH2) narilo, CH2 (CH2) nX (CH2) nheteroarilo, NH (CH2) nCONR2, XCONR (CH2) nNR2, N [(CH2) nXCOOR] CO (CH2) narilo, N [(CH2) NXR] CO (CH2) narilo, N [(CH2) NXR] CO (CH2) nXarilo, N [(CH2) NXR] SO2 (CH2 ) narilo, N [(CH2) nNRCOOR] CO (CH2) narilo, N [(CH2) nNR2] CO (CH2) narilo, N [(CH2) nNR2] CO (CH2) nNR15 aryl, N [( CH2) nNR2] SO2 (CH2) n-aryl, N [(CH2) NXR] CO (CH2) n-heteroaryl, N [(CH2) NXR] CO (CH2) n X-heteroaryl, N [(CH2) NXR] SO2 (CH2) nheteroarilo, N [(CH2) nNRCOOR] CO (CH2) nheteroarilo, N [(CH2) nNR2] CO (CH2) nheteroarilo, N [( CH2) nNR2] CO (CH2) nNR-heteroaryl, wherein the non-adjacent CY2 groups substituted also by X, R1 and R3, together also, -NC (CF3) -N-, -N-CR = N-, -NN = N-, YH, A, Hal, OR1, N (R1) 2, E-R 1 A alkyl or cycloalkyl, where one or more H atoms may be replaced by Hal and / or one or more non-adjacent CH2 groups may be replaced by X, Hal denotes F, Cl, Br or IRH or A, germ radicals R together also denote H or A, germ radicals R together also - (CH2) 5, - (CH2) 4- or - (CH2) n -X- (CH2) n, or - (CH2) NZ- (CH2) n, R4 R5 H - (CY2) ne- (CY2) n-XR1, (CH2) 2OH, (CH2) 3OH, (CH2) 2NRR1, (CH2 ) 3NRR1, (CH2) 2CH (OH) CH2OH, (CH2) 2CH (OH) CH2NRR1, (CH2) 2CH (OH) CH2NR (CH2) 2NRR1, (CH2) 2CH (OH) CH2NR5 (CH2) 2NR, (CH2) 2CH (OH) CH2-E-R 1, Q or (CH2) 2CH (OH) CH2NR (CH2) 2OR, E NR1SO2-, -SO2NR1-. -CONR1-, -NR1CO-, -COO-, -OOC-, NR1CONR1-, -OCONR1-, -NR1COO, -CSNR1-, 30 NR1CS-, -NR1CSNR1-, -SCONR1-, -NR1COS-, -OCSNR1-, NR1CSO-, SCSNR1-, -NR1CSS or XO, S or NR1 single bond, Q (CH2) Phal, CHO, COR a, (CH2) pra, (CH2) Pocora (CH2) pXR1, (CH2) pNCOR1, (CH2 ) pN (R1) 2, (CH2) pOR1, (CH2) Pocon (R1) 2, (CH2) pOCOOR1, (CH2) pNHCON (R1) 2, (CH2) pNHCOOR1, (CH2) pCN, (CH2) pCOOR1, (CH2) pE- (CH2) pR1, (CH2) pE- (CH2) Pra, can be nonadjacent groups also substituted CH2- X. OR, NHR, NR2, NR (CH2) n-aryl, NR (CH2 ) nOR, COOR, radical N-pyrrolidone, OCOR, NR (CH2) nNR2, N [(CH2) nNR2] CO (CH2) n-aryl, N [(CH2) nNHCOOR] CO-aryl, R1, N [CH2 ( CH2) nOR] 2, NR (CH2) nNCOOR, X (CH2) nX (CH2) NXR, NR (CH2) nX (CH2) nOH, NR (CH2) nO (CH2) nOH, (CH2) nCOOR, O (CO ) NR (CH2) nOR, O (CO) (CH2) nNR2, NR (CH2) nNR2, N [(CH2) nNR2] CO (CH2) n-aryl, N [(CH2) NXR] CO (CH2) n- aryl, N [(CH2) NXR] CO (CH2) n-heteroaryl, N [(CH2) nNR2] CO (CH2) n-heteroaryl, N [(CH2) nNR2] CO (CH2) NR1, N (R) ( CH2) nN (R) COOR, XCOO (CH2) nNR2, OSO2A, OSO2CF3, OSO2Ar, OCONR2, OCH2 (CH2) nNR2 Z CH2, X, CHCONH2, CH (CH2) nNR1COOR1, CHNR1COOR1, CHCON (R 1) 2, NCO, CH (CH2) nCOOR1, NCOOR1, CH (CH2) nOH, N (CH2) nOH, CHNH2, CH (CH2) nN ( R1) 2, CH (CH2) nN (R1) 2 C (OH) R1, CHNCOR1, NCoR1, N (CH2) n-aryl, N (CH2) nheteroarilo, CHR1, NR1, CH (CH2) n-aryl, CH (CH2) n-heteroaryl, CH (CH2) NR1, N (CH2) nCOOR1, CH (CH2) nX (CH2) NR1, CH (CH2) nX (CH2) NR, N (CH2) NCON (R 1) 2, XCONR1 (CH2) nN (R1) 2, CO (CH2) NR1, CO (CH2) NR1, CO (CH2) nXR1, SO2 (CH2) NR1, O (CH2) nN (R1) 2 X (CH2) nN ( R1) 2, NCO (CH2) nN (R1) 2, CHRA, NRa, R6 aryl or heteroaryl unsubstituted or mono- or polysubstituted, which may be substituted by Hal, NO2, CN, A, oR, OCOR, COR , NR2, CF3, OCF3, OCH (CF3) 2, Hal, NO2, CN, OR, A, - (CY2) n-OR, -OCOR, - (CY2) n-CO2R, (CY2) n-CN, - NCOR, -COR or - (CY2) n-NR2, R 7 (C = O) -R, (C = O) NR2, (C = O) -OR, H or A, where R5 and R7 can together also mean - (CH2) n-, m 0, 1 or 2 n 0, 1, 2, 3, 4, 5, 6 or 7 and p 0, 1, 2, 3, 4, or 5, preferably 2 or 3 S 0, 1 , 2, 3, 4, 5, 6 or 7, preferably 0, and pharmaceutically usable solvates, tautomers, salts and estereoisomer I, including mixtures thereof in all ratios.