Modulatory effect on B cell functions of mesenchymal stromal cells

In this study, we defined an in vitro inflammatory condition consisting of interleukin-beta and tissue necrosis factor-alpha and showed that naive MSCs in the inflammatory condition, could be turned into pro-inflammatory cells. We investigated pre-treatment conditions to improve MSCs’ anti-inflammatory properties and we found the use of cytokines including INF-gamma could enhance indoleamine 2,3-dioxygenase(IDO) activity and relieve pro-inflammatory changes when encountered the in vitro inflammatory condition. We believe that this result could contribute in the development of cell therapeutics using mesenchymal stem cells with enhanced anti-inflammatory properties.