PK-PD correlation of anti-infective agents for dose adjustment in one severe burn child with sepsis.

Altered pharmacokinetics in patients with major burns may result in anti-infective plasma concentrations below those required to be effective against the common pathogens encountered in burn patients. Altered fluid volumes and increased renal blood flow in these patients are the main factors responsible for pharmacokinetic changes that require higher doses, reduction on time dose intervals or both of them.