The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients

Objective To investigate the influence of combined supplementation of glutamine (Gln) and recombinant human growth hormone (rhGH) on the protein metabolism in severely burned patients. Methods Sixty severely burned patients were enrolled in the study and were randomly divided into control(C, n=20), glutamine (Gln, n=20) and Gln with rhGH (Gln+rhGH, n=20) groups. The patients in C group received glycin as the placebo, while those in Gln group took Gln orally in dose of 0.5 g·kg -1 ·d -1 during 1 14 postburn days (PBDs). For the patients in Gln+rhGH group rhGH was administered subcutaneously in dose of 0.2 U·kg -1 ·d -1 in addition to glutamine in same dosage beginning on the 7PBD for 7 days. The plasma Gln concentration in the 3 groups of patients was determined on the 1st , 7th and 14th PBD and the plasma albumin level was determined on 14th and 21st PBD. The wound healing rate of the patients within 30 PBDs and the total hospital stay days were recorded. Results The plasma Gln concentration in Gln+rhGH group of patients was evidently higher than that in C group after 7 PBD [(452.28±21 72)μmol/L vs (325.12±25.34)μmol/L,P0.05]. The plasma albumin level in Gln+rhGH group was obviously higher than that in C and Gln groups on the 21st PBD (P0.05). The wound healing rate in Gln+rhGH group was evidently higher than that in Gln and C groups on the 30th PBD(P0.05). The total hospital stay days in Gln+rhGH group were obviously less than that in C and Gln groups (P0.05 or 0.01). Conclusion Combined administration of Gln and rhGH could be beneficial to the elevation of plasma Gln level in severely burned patients and the systemic protein synthesis was therefore enhanced and the wound healing rate was improved.