The Comparison of the Blood Level of 25‑Hydroxyvitamin D3 in Healthy Adult and Patients with Herpes Zoster

Background: This study compared serum levels of 25-hydroxyvitamin D3 in healthy adults with those in patients with herpes zoster. Methods: A total of 1,483 subjects were selected among adults (aged ≥50 years) who had visited a health promotion center from October 1, 2014, to July 15, 2015. During the same period, a total of 30 subjects were selected among adults (aged ≥50 years) who were hospitalized for herpes zoster. 25-hydroxyvitamin D3 was measured using a chemiluminescence immunoassay. Results: Multiple factors can influence herpes zoster incidence, such as sex, smoking, drinking, season, age, and height. After adjusting for these factors by logistic regression analysis, we found that the effect of serum levels of 25-hydroxyvitamin D3 on herpes zoster was statistically different between the two groups (odds ratio, 0.901; 95% confidence interval, 0.838–0.969). Conclusion: The differences in the serum levels of 25-hydroxyvitamin D3 between the two groups were statistically significant. As 25-hydroxyvitamin D3 increased, the incidence of herpes zoster decreased.