Anti-Yo antibody associated paraneoplastic cerebellar degeneration in a patient with a metastatic carcinoma -A case report

Introduction: Paraneoplastic cerebellar degeneration (PCD) is a collection of neurological disorders resulting from tumor induced autoimmunity against cerebellar antigens. There are mutiple antibodies associated with PCD. Of these Anti Yo antibody is considered as one of the most important antibodies. Between 90 and 98% of patients with cerebellar ataxia and anti-Yo antibodies have a cancer detected.3,4 The vast majority of which are pelvic and breast cancers. Case Report: 47 year old lady presented with symptoms suggestive of subacute onset pancerebellar degeneration. The evaluation showed the positivity of Anti Yo Antibody in her and on extensive evaluation, she was found to be having a lymph node metastasis from a probable ovarian malignancy without the evidence of the primary in the ovary. Keywords: Paraneoplastic cerebellar degeneration, Anti Yo antibody, lymph node metastasis.