Computer game environment for assessment of self-initiated behavior and measurement of its neural correlates using fMRI

A novel computer game environment was designed to assess self-initiated motivated behavior and was used to measure its neural correlates in healthy subjects using functional magnetic resonance imaging. The results show a network of brain regions involved in these processes, including dorsolateral prefrontal, medial prefrontal and posterior parietal cortices. Our paradigm could potentially be used as a basis for assessment and rehabilitation method of self-initiated behavior and apathy.