The expression and clinical significance of lncRNA-uc003jsd.1 in congenital microtia

Objective To investigate the expression of long non-coding RNA(lncRNA) uc003jsd.1 in congenital microtia and its clinical significance. Methods Real-time quantitative polymerase chain reaction (Real-time PCR) was used to detect the expression of lncRNA-NR_028308 in the residual ear cartilage and normal ear cartilage of 8 patients with microtia. Results The expression of uc003jsd.1 was significantly higher in the residual ear cartilage (P=0.015) than paired normal tissues. Conclusions LncRNA-uc003jsd.1 is up-regulated in the cartilage of the congenital microtia, suggesting a certain relationship with the development of congenital microtia. Key words: Congenital microtia; lncRNA; uc003jsd.1