A kind of method preparing ritonavir

A kind of method preparing ritonavir being applied in pharmaceutical technology field, under the conditions of alkalescence and organic solvent, using DEPBT as condensing agent, N ‑[ N Methyl N [(2 isopropyl 4 thiazolyl) methyl] amino carbonyl] L valine and (2S, 3S, 5S) 5 amino 2 ( N ((5 thiazolyl) methoxycarbonyl group) amino) 1,6 diphenyl 3 hydroxyhexane carry out into amide and react to obtain ritonavir；N [N methyl N [(2 isopropyl 4 thiazolyl) methyl] amino carbonyl] L valine and (2S, 3S, 5S) mol ratio of 5 amino 2 (N ((5 thiazolyl) methoxycarbonyl group) amino) 1,6 diphenyl 3 hydroxyhexane is 1:1 4；N [N methyl N [(2 isopropyl 4 thiazolyl) methyl] amino carbonyl] L valine is 1:1 5 with the mol ratio of DEPBT.The method DEPBT low price, is effectively reduced the cost of raw material, is suitable for industrialization, generation of reduced contamination, post-processing operation simply and all becomes solubility effluent brine, and environment is the most friendly, simple to operate, product yield is high, and can be easily separated purification, is suitable for industrialized production.