The diagnostic significance of plasma miR-10b for esophageal cancer

Objective To evaluate the diagnostic significance of plasma miR-10b for esophageal cancer(EC).Methods Twenty-nine patients with EC and 16 healthy controls were recruited.Total RNA was extracted from plasma samples for measurement of miR-10b using RT-qPCR.The correlation analysis was performed.Results The miR 10b was significantly down-regulated in the patients with EC than that in healthy controls,and also significantly down regulated in EC patients at early stage.The sensitivity and specificity of miR-10b for EC were 81.3% and 100.0%,respectively.Plasma miR-10b showed no significant correlation with cancer stages,pathological types,differentiation or nodal metastasis.Conclusion Plasma miR-10b may play a key role in the early detection of EC.