Treatment of locally advanced non-small cell lung cancer: Agreement and disagreement

Lung cancer has become the most frequent malignant tumor in the world which its mortality and morbidity is increasing fastest among all the cancers, and it also has become the No.1 malignant tumors which is harmful to human health and life, and the first killer in all cancers. .Complete surgical resection is currently the best treatment modality for lung cancer. However, only one third of patients with lung cancer can be identified as operative candidates, For the other two thirds is inoperable, because they have late disease with distant metastasis or locally advanced lung cancer involving neighboring organs. Recently, introduction of the theory and technique of cardiovascular surgery into lung cancer surgery has made possible en bloc resection of the lung combined with part of the involved left atrium, aorta, superior vena cava, and pulmonary artery. It also made many advances for the patients with locally advanced non-small cell lung cancer lung cancer, who were thought as surgical contraindication or no curable cases, not only got complete resection of the tumor, but also had long-term survival and god life quality without evidence of recurrence and distant metastasis of the cancer.