SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND THEOPHYLLINE IN PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETRIC METHOD

A simple, precise, accurate, rapid and economical spectrophotometric method have been developed for simultaneous estimation of Montelukast sodium and Theophylline in pure and in combined tablet dosage form. Method-1 simultaneous equations and Method-2 Qabsorbance Ratio method by using nm 287 nm and 271 nm as absorbance maxima (λ max)for Montelukast sodium and Theophylline respectively and 280 nm (isoabsorptive point). A water was used as Solvent. Linearity was observed in the concentration range of 4-24 µg/ml for Montelukast sodium and 2-24 µg/ml for Theophylline respectively. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. Pharmaceutical Sciences