Fujiwara–Moritani Reaction of Weinreb Amides using a Ruthenium-Catalyzed C−H Functionalization Reaction

The ruthenium-catalyzed Fujiwara–Moritani reaction (oxidative-Heck reaction) of Weinreb amides is reported herein. The reaction affords exclusively ortho-C−H olefination products, has excellent substrate scope and tolerates halogen functionalities, which increase the synthetic utility of the method. A variety of activated olefins as well as styrenes can be employed as coupling partners.