The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release

Mei Huang,Anna R. Felix,Sunoh Kwon,David Lowe,Tanya L. Wallace,Luca Santarelli,Herbert Y. Meltzer

The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release

2014

Mei Huang
Anna R. Felix
Sunoh Kwon
David Lowe
Tanya L. Wallace
Luca Santarelli
Herbert Y. Meltzer

Rationale Alpha-7 nicotinic acetylcholine receptor (nAChR) agonists may ameliorate cognitive deficits in schizophrenia, in part, because of their ability to enhance dopaminergic and cholinergic neurotransmission.

Keywords:

Muscarinic acetylcholine receptor M3
Endocrinology
Nicotinic acetylcholine receptor
Nicotinic agonist
Internal medicine
Muscarinic acetylcholine receptor
Alpha-7 nicotinic receptor
Alpha-4 beta-2 nicotinic receptor
Muscarinic acetylcholine receptor M4
Ganglion type nicotinic receptor
Psychology
Pharmacology

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