Platelet-derived microparticles may influence the development of atherosclerosis in diabetes mellitus.

Abstract We investigated the association between low-density lipoprotein (LDL), triglycerides, and platelet activation in 18 patients with hypertension age 41–64 years and 18 with diabetes mellitus aged 43–70 years. Platelet P-selectin positivity and the microparticle level (indicators of activation) were both significantly higher in the diabetics than in healthy controls (P-selectin: 28.0% ± 7.5% vs. 7.3% ± 4.2%, P P P P