AB0251 ASSESSMENT OF CARDIOVASCULAR RISK IN RHEUMATOID ARTHRITIS AND ITS RELATION WITH LEPTIN AND INTERLEUKIN-6

Background In rheumatoid arthritis patients the risk of cardiovascular affection is 2–3 times higher than the general population (Hollan, Meroni et al. 2013), with increased morbidity and mortality(Perles, Sanchez et al. 2013). This is due to increase in the traditional and nontraditional risk factor(Skeoch and Bruce 2015). Objectives The aim of this study is to determine the cardiovascular risk in patients with RA using four established CV risk algorithms Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation Score (SCORE], Reynolds Risk Score (RRS), Q II Risk Score and there relation with serum levels of leptin and interleukin-6 (IL-6). Methods Sixty seven RA patients were enrolled in this study. The 10-year CVR for RA patients were calculated using FRS, SCORE, RRS and Q II Risk Score. Serum leptin and IL-6 were estimated. Results The results showed a significant difference between higher leptin values and disease activity, obesity, positive RF and longer disease duration, On the other hand, we found a significant difference between higher IL-6 values and disease activity, and hypertriglyceridemia. As regarding correlations of IL-6 and Leptin with different cardiovascular scores, there were no significant correlations with exception of moderate significant correlation between IL-6 and RRS (r= 0.42, P Conclusion New models of CVD risk prediction incorporating RA specific variables or imaging techniques are needed. References [1] Hollan, I., P. L. Meroni, J. M. Ahearn, J. C. Tervaert, S. Curran, C. S. Goodyear, K. A. Hestad, B. Kahaleh, M. Riggio and K. Shields (2013). ”Cardiovascular disease in autoimmune rheumatic diseases.”Autoimmunity reviews12(10): 1004-1015. [2] Perles, C. M., J. A. Sanchez, B. Garcia-Magallon and C. S. Gomez (2013). “Artritis reumatoide (II).” Medicine-Programa de Formacion Medica Continuada Acreditado 11(30): 1850-1855. [3] Skeoch, S. and I. N. Bruce (2015). ”Atherosclerosis in rheumatoid arthritis: is it all about inflammation?” Nature Reviews Rheumatology11(7): 390. Disclosure of Interests None declared