Content detecting method for Ibuprofen, chlorphenamine maleate and Pseudoephedrine Hydrochloride compound preparation

A content detecting method for pro-pseudo-chlorpheniramine compound preparation uses octadecyl silance bonding colloidal silica as packing agent. The mobile phase is monopotassium phosphate, methanol and triethyl-amine and the detecting wavelength is 215-225nm. Dissolve suitable pro-pseudo-chlorpheniramine preparation in the need testing solution with phosphate buffer solution under ultrasonic sound condition. Dissolve suitable ibuprofen, hydrochloric acid pseudoephedrine and chlorphenamine Maleate in the comparison solution with phosphate buffer solution under ultrasonic sound condition. Take each 10-20 mul of the need testing solution and the comparison solution accurately and inject into liquid chromatograph spectrometer and record chromatogram graph. Use peak acreage to calculate the content to ibuprofen, hydrochloric acid pseudoephedrine and chlorphenamine Maleate with the external standard method. It can confirm the content to three kind of component in compound preparation by using one mobile phase with the sententious and fast virtues to inspect the stability to the production and control the procreative quality of industrialization.