A modular approach to cyclic tetrapeptides related to histone deacetylase inhibition: synthesis of epi-microsporin A

Abstract A short new route to the unusual amino acid component ( S )-2-amino-8-oxodecanoic acid (Aoda) of some important HDAC inhibitors has been developed using cross metathesis reaction as the key step. An extension of the study employing grafting of a macrocyclic scaffold through cross metathesis has proved to be highly efficient for the synthesis of an isomer of the cyclic tetrapeptide HDAC inhibitor microsporin.