Unique pattern of metastasis to the adenexa in ALK rearranged non-small cell lung cancer.

e19036 Background: NSCLC most commonly metastasizes to the brain, bone, liver and adrenal glands. Recent observation of stage IV ALK rearranged NSCLC metastatic to the adnexa in our clinic led to the current study to estimate the frequency of metastasis to the female reproductive system. Methods: A retrospective chart review of female patients with stage IV ALK rearranged NSCLC was performed. Relevant charts were reviewed for pelvic imaging notable for ovarian, adnexal, or pelvic mass or enlargement. Results: Twenty patients met the requirements for chart review: female, NSCLC, and the presence of an EML4-ALK. Of these 20 cases, 16 included imaging of the pelvis by computed tomography as part of work-up for systemic disease; one patient had prior hysterectomy-oophorectomy and was excluded. 5 of 15 charts with pelvic imaging were notable for ovarian enlargement or mass. 2 of these women underwent therapeutic intervention directed at their ovarian masses. Conclusions: The finding of adnexal abnormalities in...