Useful compositions as protein kinase inhibitors.

A compound of formula I: (See formula) or a pharmaceutically acceptable salt thereof, where: W is CH or N, where H is optionally replaced by (C1-C6) alkyl or NH2; Ring B is an optionally substituted 6-membered aryl ring, which has 0-3 nitrogen; R1 is an optionally substituted phenyl, pyridyl or pyrimidyl ring; wherein said optional substituent of Ring B or R1 is selected from 1-3 R3 groups, where each R3 is, independently, oxo, halogen, -B (OH) 2, -Ro, -ORo, - SRo, 1,2-methylenedioxy , 1,2-ethylenedioxy, -CO2 (C1-4 aliphatic), a 5-6 membered heterocyclic ring optionally substituted with Ro, phenyl optionally substituted with Ro, -O (phenyl) optionally substituted with Ro, - (CH2) 1 - 2 (phenyl) optionally substituted with Ro, -CH = CH (phenyl) optionally substituted with Ro, -NO2, -CN, -NHRo, -N (Ro) 2, -NRoC (O) Ro, -NRoC (S) Ro, - NRoC (O) N (Ro) 2, -NRoC (S) N (Ro) 2, - NRoCO2Ro, -NRoNRoC (O) Ro, -NRoNRoC (O) N (Ro) 2, -NRoNRoCO2Ro, - C (O) C (O) Ro, -C (O) CH2C (O) Ro, -CO2Ro, -C (O) Ro, -C (S) Ro, - C (O) N (Ro) 2, -C (S) N (Ro) 2, -OC (O) N (Ro) 2, -OC (O) Ro, - C (O) N (ORo) Ro, -C (NORo) Ro, -S (O) 2Ro, -S (O) 3Ro, -SO2N (Ro) 2, -S (O) Ro, -NRoSO2N (Ro) 2, -NRoSO2Ro, -N (ORo) Ro, -C (= NH) - N (Ro ) 2 or - (CH2) 0-2NHC (O) Ro; where each independent appearance of Ro is selected from hydrogen, C1-6 aliphatic, a 5-10 membered heteroaryl or heterocyclic ring, phenyl, -O (phenyl), -CH2 (phenyl), 5-membered heterocyclic ring, where each Ro it is optionally substituted with J, where J is aryl, phenyl, heteroaryl, NH2, NH (C1-4 aliphatic), N (C1-4 aliphatic) 2, NH (CH2) phenyl, halogen, - NHSO2 (C1-4 aliphatic) , -NHCO2 (C1-4 aliphatic), C1-4 aliphatic, OH, O (C1-4 aliphatic), NO2, CN, CO2H, -CO (5-6 membered heterocyclic ring), 5-6 membered heterocyclic ring , -CO2 (C1-4 aliphatic), -O (C1-4 haloaliphatic) or halo (C1-4 aliphatic), or two Ro are taken together with the atom or atoms to which they are attached to form a heterocyclyl ring, aryl or 5-8 membered heteroaryl or a 3-8 membered cycloalkyl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen or sulfur; where each group of J is optionally substituted with J?, where J? is NH2, NH (C1-4 aliphatic), N (C1-4 aliphatic) 2, NH (CH2) phenyl, halogen, -NHSO2 (C1-4 aliphatic ), - NHCO2 (C1-4 aliphatic), C1-4 aliphatic, OH, O (C1-4 aliphatic), NO2, CN, CO2H, -CO (5-6 membered heterocyclic ring), 5-6 heterocyclic ring members, - CO2 (C1-4 aliphatic), -O (C1-4 haloaliphatic) or halo (C1-4 aliphatic), where each of the groups J? is optionally substituted with a C1-4 aliphatic group, halogen, where each of the C1-4 aliphatic groups of J? is unsubstituted; where each aliphatic or heteroaliphatic group or non-aromatic heterocyclic ring is optionally substituted with R3, = O, = S, = NNHR *, = NN (R *) 2, = NNHC (O) R *, = NNHCO2 (alkyl), = NNHSO2 (alkyl) o = NR *, where each R * is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group, where the optional substituents on the R * aliphatic group are selected from a 5-6 membered heterocyclic ring , heteroaryl, aryl, NH2, NHSO2R *, NH (C1-4 aliphatic), N (C1-4 aliphatic), halogen, C1-4 aliphatic, OH, O (C1-4 aliphatic), CO (heterocyclic ring of 5 -6 members), NO2, CN, CO2H, CO2 (C1-4 aliphatic), O (C1-4 aliphatic halo) or halo (C1-4 aliphatic), where each of the aforementioned C1-4 aliphatic groups of R * is unsubstituted; where each nitrogen of a non-aromatic heterocyclic ring is optionally substituted with - (C1-6 aliphatic) 2, -R +, -N (R +) 2, -C (O) R +, -CO2R +, -C (O) C (O ) R +, - C (O) CH2C (O) R +, -SO2R +, -SO2N (R +) 2, -C (= S) N (R +) 2, -C (= NH) -N (R +) 2 or - NR + SO2R +; where R + is hydrogen, an optionally substituted C1-6 aliphatic group, optionally substituted phenyl, -O optionally substituted -O (phenyl), -CH2 (optionally substituted phenyl), - (CH2) 1-2 (optionally substituted phenyl); -CH = CH (phenyl) optionally substituted; or a 5-6 membered heteroaryl or heterocyclic ring, unsubstituted, having one to four heteroatoms independently selected from oxygen, nitrogen or sulfur, where the optional substituents on the aliphatic group or the R + phenyl ring are selected from NH2 , NH (C1-4 aliphatic), N (C1-4 aliphatic) 2, halogen, C1-4 aliphatic, OH, O (C1-4 aliphatic), NO2, CN, CO2H, CO2 (C1-4 aliphatic), O (C1-4 aliphatic halo) or halo (C1-4 aliphatic), where each of the above C1-4 aliphatic groups of R + is unsubstituted, or two R + are taken together with the atom or atoms to which they are attached to forming a 5-8 membered heterocyclyl, aryl or heteroaryl ring or a 3-8 membered cycloalkyl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen or sulfur; and Ring A is an optionally substituted ring selected from: (See formula) where said optional Ring A substituent is selected from -OH, -NH2 or -CH3.