RATLARDA OLUŞTURULAN DENEYSEL ARTRİT MODELİNDE İNTRAARTİKÜLER OLARAK VERİLEN HYALURONİK ASİT VE METİL PREDNİSOLON ASETATIN SİNOVYAL DOKU ÜZERİNE ETKİLERİ/ EFFECTS OF INTRAARTlCULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON SYNOVIAL TlSSUE IN A MO

Intraanikuler olarak uygulananhyaluronik asit (HA) ve metil prednisolon asetat (MPA) tedavilerinin enflamatuar artritler uzerine olan etkilerini arastinnak icin deneysel bir calisma yapildi. 40 adet erkek ratin sa~ arka diz eklemleri icine 0.2 ml %1'lik fonnalin verilerek deneysel artrit olusturuldu. Ilac verilmesinden bir hafta sonra 10 rat oldurtilerek artritin olustugu histopatolojik olarak belirlendi. Kalan 30 rat 3 gruba aynldi. Birinci gruba 0.05 ml intraartikuler HA (HA grubu), ikinci gruba 0.05 ml intraartikuler MPA (MPA grubu) verildi. Ucuncu gruba ise intraartikuler 0.05 ml serum fizyolojik verilerek kontrol grubu olusturuldu. Tedaviler artrit olusturulduktan sonra 7. Gun, 14. Gun ve il. gun uygulandi. Uygulanan bu tedavilerin bitiminden 15 gun sonra ratlar olduruldu ve alinan ornekler, histopatolojik olarak incelendi. Yapilan incelemede; HA tedavisi ile sinovyal dokuda kontrol grubuna gore anlamli iyilesme olmadigi goruldu (p>O.05). MPA grubunda ise sinovyal doku iyilesmesi kontrol grubuna gore anlamli olarak yuksek bulundu (p 0.05). Enflamatuar artrit tedavisinde intraartikuler olarak uygulanan MPA'in sinovyal doku iyilesmesinde daha etkili gibi gorunmesine ragmen, HA'e gore bariz bir ustunlugunun olmadigi sonucuna vanldl. Anahtar kelimeler: Deneysel artrit, sinovyal doku, hyaluronik asit, metil prednisolon asetat. SUMMARY This experimental study was peiformed to determine the effeets of intraartieular hyaluronie acid (HA) and methyl prednisolone acetate (MPA) in inflammatory arthritis. 0.2 ml 1% formaline wereinjeeted to the posteri'or right knee joints of 40 male rats. One week after the injeetions, 10 rats werekilled and arthritis was determined histopathologieally. The remained 30 rats were divided to three groups. First group received intraarticularly 0.05 ml HA (HA group), second group 0.05 ml MPA (MPA group) and third group 0.05 ml saline as controls. The injections were performed at 7., 14. and 21. d-ays after the arthriris. 15 days after the end of these treatments, rats were killed and sections were examined his/opa/hologically. There was no significantly differenee in synovial tissue healing between HA and control groups (p>O.OS). Synovial tissue healing was significantly high in NlPA group compared to the control group (p O.OS). it was concluded that although intraarticular MPA seems more effective on synovial tissue healing in inflammatory arthritis it has no evident superiority to HA. Key Words: Experimental arthritis, synovial tissue, hyaluronic acid, methyl prednisolone aeetale.