Safety of micafungin in infants: insights into optimal dosing

Introduction: Invasive Candida infections are a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Micafungin is a promising therapeutic option for treatment of invasive fungal infections in infants given its safety profile in older children and adults. Understanding micafungin safety in infants is particularly important because antifungals are most often used in premature infants with multiple underlying medical conditions in a critical care setting. Areas covered: This article reviews the literature evaluating the safety profile of micafungin in infants and offers recommendations for optimal dosing for treatment of invasive candidiasis in the NICU setting. The review has been performed using a Medline search in September 2010 for related articles from 1990 to the present with the Mesh related terms ‘micafungin’ and ‘safety’ in combination with the free words ‘antifungal’, ‘candidiasis’, ‘drug toxicity’, ‘infant, premature’ and ‘infant, newborn’. Expert opinion: Despite th...