Research progress on palmitoylation of postsynaptic density protein 95

Postsynaptic density protein 95(PSD-95), the most abundant and significant synapse scaffolding protein at excitatory synapses, is a hallmark of synaptic function.Proteins palmitoylation is one of the important post-translational modifications, which is occurred more frequently in the nervous system than in other organs.Palmitoylation-dependent regulation of PSD-95 has become a research hotspot in the fields of neuroplasticity and neuropsychiatric diseases. Key words: Synaptses; Proteins; N-Methylaspartiate; Isoxazoles