Liquid Crystallinity and Biological Activity of a Novel Amphiphilic Compound

We have designed an amphiphilic compound in which phenylpyrimidine and D-glucamine are connected via a flexible spacer. The compound shows two thermotropic lamellar bilayer mesophases with different layer spacings. The liquid-crystalline compound showed cytostatic activity against A549 human lung carcinoma cell lines, however an amphiphilic phenylpyrimidine derivative, D-glucamine, and an equimolar mixture of them were not active on cell lines under identical conditions.