Efficient Synthesis of N-4 Alkyl Derivatives of 2′, 3′-Dideoxycytidine (ddC)
1999
Abstract The C-4 triisopropylphenylsulfonyl (TPS) group of the 2′,3′-dideoxyuridine derivative 2 is readily displaced in situ by nitrogen nucleophiles forming N-4 substituted ddC in acceptable yields.
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