Palladium and Copper Catalyzed Sonogashira Decarboxylative Coupling of Aryl Iodides and Alkynyl Carboxylic Acids.

Abstract A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reaction of aryl halides and alkynyl carboxylic acids has been developed. Low molecular weight acids, to introduce small building blocks, were specifically used. This methodology is easy to implement and uses common reactants and catalysts.