Comparison of the Effect of 99mTc-DPD and 99mTc-MDP on Experimentally-induced Osteoarthritis in the Stifle Joint of the Dog

This study was designed to evaluate the effect of 99m Technetium-dicarboxypropane diphosphonate ( 99m Tc-DPD) and 99m Technetium-methylene diphosphonate ( 99m Tc-MDP) on bone scan image quality and time in dogs with osteoarthritis. The left cranial cruciate ligament (CrCL) in ten healthy adult Beagle dogs was transected under general anesthesia. The dogs were assigned to 99m Tc-DPD-injected or 99m Tc-MDP-injected groups. Stifle joint scintigraphy was performed after intravenous injection of 10 mCi 99m Tc-DPD or 99m Te-MDP. Scintigraphy was