Phenolic cyclisation. Part I. Novel synthesis of 1-substituted isoquinoline and spiro[cycloalkane-1,1′-isoquinoline] derivatives and its application to the total synthesis of isoquinoline alkaloids

Novel syntheses of 1-substituted isoquinoline and spiro[cycloalkane-1,1′-isoquinoline] derivatives were achieved by condensation of 3-hydroxyphenethylamine with carbonyl compounds, and application of this method led to the total synthesis of (±)-coreximine.