Nowe aspekty leczenia choroby trzewnej

Celiac disease affects 1% of the population. Patients with celiac disease, due to atrophy of the intestinal epithelial epithelial atrophy, are at risk of deficiencies in both minerals and vitamins due to decreased intestinal absorption. Among people with celiac disease who do not use a gluten-free diet, the most frequently underestimated parameters are iron, zinc, vitamin B12, B6 and D. In addition, there is a non-invasive, specific and reliable test showing the presence of immunogenic gluten peptides (GIP) in the urine. There is a positive GIP correlation to the amount of gluten consumed. It is an important factor that monitors the reliability of adherence to dietary recommendations excluding gluten. Currently, the only sure method of treating celiac disease is a gluten-free diet, which should be maintained throughout life, but research on new, easier and less absorbing methods is underway. Among the so-called Future methods can include, among others: splitting proline-rich gluten into smaller peptides: endopeptidase proliferation, ALV003, lactic acid bacteria, probiotics, preventing the absorption of toxic gliadins: Larazotide, POLY synthetic polymer, anti-gliadin antibodies of egg yolk. The aim of the work is to present the latest information on methods of diagnosis and treatment of celiac disease. Attention was also paid to the malabsorption syndrome occurring in celiac disease. Additionally, the analysis of the nutritional status and selected laboratory parameters of 63 patients hospitalized due to the malabsorption syndrome was performed.