TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

Polarized CD4+ T cells can demonstrate considerable plasticity depending on the cytokine milieu they encounter. O'Shea and colleagues show that retinoic acid induces the microRNA miR-10a, which suppresses the transcription factor Bcl-6 to prevent conversion into follicular helper T cells.