MICROSYNTHESIS OF A NOVEL HERBICIDE,PROPYL 4-[2-[(4,6-DIMETHOXY-2-PYRIMIDINYL)OXY] BENZYLAMINO]BENZOATE

ZJ273,propyl 4-[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzylamino]benzoate,is a novel herbicide.The microsynthetic method of the compound was developed from 4,6-dimethoxy-2-pyrimidine,propyl(4-benzylamino) benzoate and phenol,and then purified by preparative-HPLC.The yield of end product was 53%.Its chemical structure was characterized by means of()~1H-NMR,MS,UV,and its chemical purity was determined to be exceed 98% by HPLC.The microsynthetic method of propyl 4[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy] benzylamino]benzoate developed sets up a basis to synthesize the radioisotopic labeled target compound.