ОСОБЕННОСТИ ТОКСИКОГЕННОЙ СТАДИИ ОСТРЫХ ОТРАВЛЕНИЙ ПСИХОФАРМАКОЛОГИЧЕСКИМИ ПРЕПАРАТАМИ У ПАЦИЕНТОВ СТАРШЕ 60 ЛЕТ С ПОЗИЦИЙ ТОКСИКОМЕТРИИ

Examinations of 406 patients aged from 60 to 93 years with acute poisoning with psychopharmacological medicines of varying severity were performed. The nomenclature of preparations that caused poisonings and combinations were analyzed. The concentrations of psychopharmacological preparations in blood and urine were monitored until they were absent in biological fluids. It was revealed that in patients of gerontological age more than half of poisonings occur as a result of combined intake of drugs of two or more pharmacological groups. It has been found that in patients older than 60 years with therapeutic concentrations of drugs in blood, symptoms of mild poisoning can be recorded in the case of use of one drug, and when combined intoxication is more severe. This category of persons is characterized by long-term excretion of psychopharmacological medicines from body during treatment, that influences the course of poisoning – can contribute to the fatal outcome as a result of prolonged intoxication and the development of life-threatening complications.