The Relationship Between Calciotropic Hormones, IGF-1, and Bone Mass Across Pubertal Stages

Background: Little is known about the changes in calciotropic hormones during puberty and their relationship to bone mass during this critical period for skeletal accretion. Objectives: Investigate changes in calciotropic hormones, IGF-1, body composition, and their associations with bone metabolism in adolescents. Methods: Post hoc analyses were performed from data on 335 healthy school children, ages 10–17 years, with hypovitaminosis D who participated in a vitamin D randomized controlled trial. Baseline serum biochemistries; hormonal studies; densitometry at the spine, hip, and total body; and body composition were used. ANOVA and regression analyses were implemented to evaluate changes in variables of interest across pubertal stages, within and between genders. Results: Bone mass and body composition parameters increased substantially across Tanner stages in both genders. Serum calcium, 1,25-dihydroxyvitamin D, and 25-hydroxyvitamin D levels did not vary by Tanner stages in both genders. Conversely, s...