Quantification of Cerebral Blood Flow in Adults by Dynamic Contrast-Enhanced NIRS: Validation against MRI

Daniel Milej,Lian He,Androu Abdalmalak,Wesley B. Baker,Udunna C. Anazodo,Sudipto Dolui,Venkaiah C. Kavuri,Mamadou Diop,William Pavlosky,Ramani Balu,John A. Detre,Adrew Kofke,Arjun G. Yodh,Keith St. Lawrence

Quantification of Cerebral Blood Flow in Adults by Dynamic Contrast-Enhanced NIRS: Validation against MRI

2018

Daniel Milej
Lian He
Androu Abdalmalak
Wesley B. Baker
Udunna C. Anazodo
Sudipto Dolui
Venkaiah C. Kavuri
Mamadou Diop
William Pavlosky
Ramani Balu
John A. Detre
Adrew Kofke
Arjun G. Yodh
Keith St. Lawrence

An optics-MRI perfusion validation study investigated whether time-resolved contrast-enhanced NIRS can measure cerebral blood flow changes induced by altering arterial PCO2. Strong correlation between flow estimates from MRI and contrast-enhanced NIRS was found.

Keywords:

Cerebral blood flow
Internal medicine
Medicine
Cardiology
light propagation
validation study
Neuroscience
Magnetic resonance imaging
dynamic contrast
Arterial pCO2
Perfusion
Biomedical engineering

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