P020 Silencing of prolyl hydroxylase 1 in intestinal microvascular endothelial cells prevents inflammation-induced endothelial dysfunction and dampens murine colitis

P019 T cell specific loss of PTPN2 results in aggravated colitis and pronounced intestinal dysbiosis as observed in Crohn’s disease patients M. Spalinger1 *, C. Chassard2, S. Kasper1, L. Biedermann1, S. Vavricka3, I. Frey-Wagner1, K. Atrott1, C. Lacroix2, M. Fried1,4, G. Rogler1,4, M. Scharl1,4. 1University Hospital Zurich, Gastroenterology & Hepatology, Zurich, Switzerland, 2ETH Zurich, Institute of Food, Nutrition and Health, Zurich, Switzerland, 3Hospital Triemli, Gastroenterology & Hepatology, Zurich, Switzerland, 4Zurich Institute for Human Physiology, University Zurich, Zurich, Switzerland