SP0173 Stratifying primary sjogren’s syndrome patients

The clinical manifestations of primary Sjogren’s syndrome (PSS) vary considerably between individual patients. The pathogenesis of PSS is not fully understood and although many aberrant biological pathways have been identified, the relationships between these pathways and clinical manifestations remain unclear. Furthermore, there is substantial heterogeneity in long-term outcomes and in health economic cost among patients with PSS. Stratification of PSS into more homogeneous subsets will facilitate better understanding of the pathogenesis of the disease, development of more cost-effective management strategies and accelerate therapeutic development programmes of targeted therapies in PSS. The establishment of several large cohorts of clinically well characterised PSS cohorts with associated biobanked materials has provided a rich resource for stratified medicine research in PSS. The growing number of datasets from clinical trials in PSS provide an excellent opportunity to evaluate the potential impact of stratified approach to therapy development in PSS. In this presentation, different approaches to identify clinically and biologically meaningful PSS subsets will be considered. In addition, the key challenges and potential future directions in Stratified Medicine in PSS will be discussed. Disclosure of Interest W.-F. Ng Grant/research support from: ElectroCore, Resolve Therapeutics, Nascient, Consultant for: GlaxoSmithKline, Novartis, Abbvie, MedImmune