Sesquiterpenoids of Illicium jiadifengpi and Their Effects on NGF-induced Neurite Outgrowth in PC12 Cells

Two new compounds, jiadifenlactone acid monomethyl ester (1) and jiadifenin (3), and five known compounds were isolated from the fruits of I. jiadifengpi. Their structures were determined using spectroscopic techniques, including 1D, 2D NMR and HR-ESI-MS experiments. The relative stereochemistry of jiadifenlactone acid monometheyl ester (1) was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells and two compounds showed promoting effects.