Features of Neurogenic Disorders and Endothelial Mechanisms of Vasoregulation in Patients with Neuropathic and Neuroischemic Forms of Diabetic Foot

The state of neurogenic and endothelial mechanisms of vasoregulatio n of microvasculature in patients with diabetic foot syndrome, depending on the nature of the main blood flow and form of necrotic lesions of feet was studied. To assess violations of regulatory mechanisms of vasoregulation and identification of adaptive reserves of microvasculature of the lower extremities precision thermometry with indirect cold test and wavelet analysis of the oscillation amplitude of skin temperature in neurogenic (0.02 - 0.05 Hz) and endothelial (0.0095 - 0.02 Hz) frequency ranges was used. The sequence of neurogenic violations and the endothelial regulatory mechanisms of vasomotion function of the microvasculature, depending on the form of diabetic angiopathy of the lower extremities were established. Investigation of skin temperature in patients with diabetic foot syndrome is a diagnostic method of diabetic polyneuropathy symptoms, endothelial dysfunction and can be used to assess treatment efficacy.