Исследования по созданию лекарственной формы на основе3-(4-нитрофенил)-5-(нонилсульфонил)-1,2,4-триазол-4-амина

Aim.To research the dosage form based on 3-(4-nitrophenyl)-5-(nonilsulfonil)-1,2,4-triazole-4-amine.Materials and methods. Based on synthetic, physical-chemical and pharmacological studies of 4-amino-5-(2-,3-,4-nitrophenyl)-1,2,4-triazole-3-thiones, the 3-(4-nitrophenyl)-5-(nonilsulfonil)-1,2,4-triazole-4-amine has been selected for further study, as in previous research this compound showed high actoprotective, antioxidant, neuroprotective activity and can find its application as a potential drug.Conclusions. A complex of physical-chemical and pharmaco-technological research have been conducted that allowed to predict the gastrointestinal tract part, where absorption will be after oral administration, and allowed to propose a model dosage form.