Sustained release tablet formulation of diethylcarbamazine

Abstract Sodium carboxymethylcellulose was successfully used in formulating a sustainedrelease tablet dosage form of diethylcarbamazine citrate, a drug of choice against human filariasis. The formulation containing DECC:NaCMC (1:7) was found to be most suitable. Urinary excretion studies in normal subjects using this formulation showed steady-state levels of DEC for about 12 h. Tablets prepared according to the formulation had a stable shelf-life of over 2 years.