High in vitro activity of synthetic 5-aminoimidazole-4-carboxamidrazones against Candida biofilms formation on nanohydroxyapatite

C Gabriel, L Grenho, AM Dias, AI Ribeiro, MF Proenca, MH Fernandes, FJ Monteiro, MP Ferraz, R Medeiros, F Cerqueira FP-ENAS/CEBIMED, Universidade Fernando Pessoa, Porto, Portugal INEB Instituto de Engenharia Biomedica, Universidade do Porto, Porto, Portugal; Faculdade de Engenharia, Departamento de Engenharia Metalurgica e Materiais, Universidade do Porto, Porto, Portugal; Centre of Chemistry, Department of Chemistry, University of Minho, Campus de Gualtar, Braga, Portugal Faculdade de Medicina Dentaria, Departamento de Farmacologia, Universidade do Porto, Porto, Portugal Molecular Oncology GRP and Molecular Biology Laboratory–Virology Service, Portuguese Institute of Oncology (IPO), Porto, Portugal Contributed equally