Variations in Clinical Parameters of Hospitalized Patients with COVID-19

Background: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) also known as COVID19, is a newly discovered virus that has been recently isolated from humans A number of researches with special emphasis on its clinical and epidemiological parameters are being carried out in various parts of the world Aim: To analyze and evaluate the clinical, laboratory and chest x ray findings of Covid-19 cases, admitted at a recently established Corona Unit of Farooq Hospital West Wood Lahore, Pakistan Study Design: Retrospective study Methods: The current study included a total of 105 COVID-19 positive cases from 9th April to 27th May 2020 94 cases were confirmed on the basis of laboratory values whereas 11 were diagnosed based on their clinical characteristics Results: Of all 105 patients admitted, 94(89 50%) were detected as laboratory-confirmed COVID-19 pneumonia with nasopharyngeal swab samples that were positive for SARS-CoV-2, whereas 11 (10 50%) were confirmed on clinical grounds The mean age was 48 18 that ranged from 12 to 78 years Majority were male patients (78 1%) Only 3 (2 9%) patients had recent travel history of abroad The most common comorbidities were Hypertension (49 39%) and Diabetes Mellitus (43 37%) The most common symptoms (fever, dry cough, and tiredness) were observed in 29 5%, serious symptoms (shortness of breath, chest pain or pressure, and loss of speech or movement) in 40% and only few cases with acute respiratory distress syndrome The mean systolic blood pressure recorded was 122 8 +/- 12 85 mm Hg and mean diastolic blood pressure 79 29 +/- 9 96 The mean oxygen saturation levels were 94 30 +/- 5 063 The mean value for chest x ray scoring was 7,50 +/- 5 6 The laboratory values were taken into account and elevated levels of C-reactive protein (CRP) were reported in 65 75% and procalcitonin levels in 58% of the patients Higher polymorph leukocytes count was observed in 34 (33%) whereas 40 cases (38 83%) of COVID-19 patients had lymphopenia D-dimers, AST, ALT levels were raised in 79 68%, 47 2% and 58 3% of patients, respectively Higher levels of serum ferritin were seen in 61 4% of cases Conclusion: The clinical, laboratory and radiological findings may play pivotal role in early detection of positive COVID-19 cases and thus help in timely therapeutics management