Suppressive effect of bone marrow cells of normal and leukemic mice on antibody production by spleen cell cultures in vitro

The suppressive activity of bone marrow cells from AKR and (CBA×C57BL)F1 mice aged 2 and 10 months in relation to the primary immune response of spleen cells to sheep's red blood cells in vitro was investigated. In leukemic AKR mice the suppressive activity of the bone marrow was shown to rise considerably until the 9th–10th month compared with that at the age of 2 months. In (CBA×C57BL)F1 mice the suppressive activity of bone marrow at these same times was unchanged.